CJC-1295 with DAC: The High-Level View

• Identity: Synthetic analogue of Growth Hormone-Releasing Hormone (GHRH).
• Action: It is a potent Growth Hormone Secretagogue (GHS), meaning it stimulates the pituitary gland to release the body’s own natural Growth Hormone (GH).
• The DAC Advantage: The Drug Affinity Complex (DAC) is a key modification that allows the peptide to bind to albumin in the blood, dramatically extending its half-life to about 6-8 days.² This allows for a sustained, steady increase in GH and subsequently in Insulin-like Growth Factor-1 (IGF-1), and necessitates dosing only once or twice a week.

The Significance of the 5mg Vial

A 5mg (milligram) vial contains 5,000 micrograms ($\text{mcg}$) of the lyophilized (freeze-dried) peptide powder. This is a large amount, making accurate preparation and calculation essential.

Reconstitution and Concentration

The lyophilized powder must be mixed with a solvent, typically Bacteriostatic Water, to create a solution for injection.³ The volume of water added determines the final concentration.

Note: The 5mg vial requires extreme care in measuring the solvent and the final dose, as even small errors in drawing the solution can result in a large dose difference due to the high concentration.

Potential Research Applications

CJC-1295 with DAC is often studied for its potential in:

• Sustained GH/IGF-1 Elevation: Offering a prolonged, steady increase in these hormones, which can be useful for long-term studies on body composition and aging.
• Increased Anabolism: Supporting the research of muscle protein synthesis and fat metabolism.
• Tissue Repair: Investigating its role in accelerating healing and recovery from injury.
• Sleep Quality: Researching the effect of increased GH on sleep architecture, as GH release is pulsatile and often peaks during deep sleep.

Crucial Caveats

• Research Product: Like most peptides, CJC-1295 with DAC is typically labeled and sold as a research chemical only and is not approved by bodies like the FDA for non-supervised human therapeutic use.
• Long Half-Life: The primary difference from CJC-1295 without DAC (Modified GRF 1-29) is the long half-life.⁶ This means that if a side effect occurs, the substance remains active in the body for up to a week, which requires careful consideration.
• Professional Guidance: Use, storage, and dosage calculations should only be performed under the strict oversight of a qualified medical professional, especially when dealing with high-concentration vials like 5mg.