Targeted Anti-Cancer Research Peptide | Selective p53 Pathway Activator | For Research Use Only

PNC-27 is a synthetic peptide engineered to bind and selectively destroy cancer cells by targeting the HDM-2 (human double minute-2) protein, which is often overexpressed in tumour cells. By mimicking part of the tumour suppressor protein p53, PNC-27 is designed to penetrate cancer cell membranes and induce membrane lysis, without affecting healthy cells.

It is currently under preclinical investigation for its potential in oncology, tumour imaging, and apoptosis pathway studies.

🔍 Key Features

• Selective Cytotoxicity – Targets tumour cells via HDM-2 recognition

• Derived from p53 Activation Domain – Mimics native tumour suppressor response

• Induces Cell Membrane Pore Formation – Causes cancer cell lysis

• Minimal Effect on Healthy Cells – Low observed toxicity in non-tumour tissues (in vitro)

• Applications in Anti-Cancer, Apoptosis & Tumour Marker Research

⚙️ Peptide Details

• Peptide Name: PNC-27

• CAS Number: 725232-44-0

• Molecular Formula: C₁₅₀H₂₂₈N₄₆O₄₃

• Molecular Weight: ~3360.7 g/mol

• Purity: ≥ 98% (HPLC Verified)

• Form: Lyophilised white powder

• Unit Size: 10mg per vial

🧊 Storage & Handling

• Storage (lyophilised): Store at –20°C, away from light and moisture

• Reconstitution: Use sterile bacteriostatic water

• Post-Reconstitution: Store at 2–8°C and use within 5–7 days

• Avoid: Repeated freeze-thaw cycles

⚠️ For Research Use Only

PNC-27 – 10mg is supplied strictly for research and investigational purposes only. It is not intended for human consumption, therapeutic use, or clinical application. Must be handled by qualified personnel in controlled laboratory environments.